Howard is allergic to nuts, particularly peanuts and pistachios; they can induce a life threatening anaphylactic reaction in him, which has a side effect of disfiguring his face horribly. He once deliberately caused this reaction by eating a granola bar to keep Leonard busy at the hospital when they were planning a surprise birthday party for him. Another time, when he was depressed about Leslie Winkle dumping him in season 2, and while he was in Las Vegas with Raj and Leonard, he tweeted that he was considering suicide by consuming a can of peanuts due to loneliness and not having his desires met.
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